01 / Renal Function

Creatinine Clearance

Creatinine Clearance · Cockcroft-Gault Equation

CrCl = [(140 − age) × weight × (0.85 if ♀)] ÷ (72 × SCr)

Patient Information

Sex

Male Female

Age

years

Weight — actual

Serum Creatinine

mg/dL

Height — optional

Obesity Adjustment (ABW)
If actual body weight exceeds 130% of IBW, Adjusted Body Weight is used automatically. ABW = IBW + 0.4 × (TBW − IBW). Height is required.

Result

Normal

— mL/min

Clinical Interpretation

Formula & Clinical Notes

The Cockcroft-Gault equation, developed in 1976, remains the most widely used basis for FDA drug-dosing labeling.
Not accurate in AKI where renal function is changing rapidly; assumes a steady-state SCr.
In obesity (BMI ≥30 or TBW > 130% IBW), using ABW instead of actual weight is recommended.
In underweight patients (TBW < IBW), use TBW as-is (do not substitute IBW).
General dose-adjustment thresholds: CrCl <50 (adjust), <30 (reduce significantly), <15 (mostly contraindicated or dialysis-dependent).
This result is a clinical decision-support aid; final prescribing decisions must account for the patient’s complete clinical picture.